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2013 Published Papers

Negri, A., Rives, M.L., Caspers, M., Prisinzano, T.E., Javitch, J.A., Filizola, M. “Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening” Journal of Chemical Information and Modeling (2013) 53: 521-526. http://www.ncbi.nlm.nih.gov/pubmed/23461591.

Gomes, I., Fujita, W., Gupta, A., Saldanha, A.S., Negri, A., Pinello, C.E., Roberts, E., Filizola, M., Hodder, P., Devi, L.A., Identification of a μOR-δOR heteromer-biased agonist with antinociceptive activity. Proceedings of the National Academy of Science USA (2013) Jul 16;110(29):12072-7. http://www.ncbi.nlm.nih.gov/pubmed/23818586.

Mondal, S., Johnston, J., Wang, H., Khelashvili, G., Filizola, M., Weinstein, H., Membrane Driven Spatial Organization of GPCRs. Nature Scientific Reports (2013) 3 (2909): 1-9. http://www.ncbi.nlm.nih.gov/pubmed/24105260.

C. S. Poultney, A. P. Goldberg, E. Drapeau, Y. Kou, H. Harony-Nicolas, Y. Kajiwara, S. De Rubeis, S. Durand, C. Stevens, K. Rehnström, A. Palotie, M. J. Daly, A. Ma'ayan, M. Fromer and J. D. Buxbaum, Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder. Am J Hum Genet 93 607--619 (2013). http://ac.els-cdn.com/S000292971300414X/1-s2.0-S000292971300414X-main.pd...

Bin Zhang, Chris Gaiteri, Liviu-Gabriel Bodea, Zhi Wang, Joshua McElwee, Alexei A Podtelezhnikov, Chunsheng Zhang, Tao Xie, Linh Tran, Radu Dobrin, et al. Integrated systems approach identfies genetic nodes and networks in late-onset alzheimer's disease. Cell, 153(3):707{720, 2013. http://dx.doi.org/10.1016/j.cell.2013.03.030.

Qian Wang, Maria Chikina, Elena Zaslavsky, Hanna Pincas, and Stuart C. Sealfon. -catenin regulates gnrh-induced fsh gene expression. Mol Endocrinol, 27(2):224{237, Feb 2013. http://dx.doi.org/10.1210/me.2012-1310.

Karani S Vimaleswaran, Diane J Berry, Chen Lu, Emmi Tikkanen, Stefan Pilz, Linda T Hiraki, Jason D Cooper, Zari Dastani, Rui Li, Denise K Houston, et al. Causal relationship between obesity and vitamin d status: bi-directional mendelian randomization analysis of multiple cohorts. PLoS medicine, 10(2):e1001383, 2013. http://dx.doi.org/10.1371/journal.pmed.1001383.

Harm van Bakel, Kyle Tsui, Marinella Gebbia, Sanie Mnaimneh, Timothy R. Hughes, and Corey Nislow. A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription. PLoS Genet, 9(5):e1003479, May 2013. http://dx.doi.org/10.1371/journal.pgen.1003479.

Eric E Schadt, Onureena Banerjee, Gang Fang, Zhixing Feng, Wing H Wong, Xuegong Zhang, Andrey Kislyuk, Tyson A Clark, Khai Luong, Alona Keren-Paz, et al. Modeling kinetic rate variation in third generation dna sequencing data to detect putative modifications to dna bases. Genome research, 23(1):129{141, 2013. http://dx.doi.org/10.1101/gr.136739.111.

Guido Scarabelli, Davide Provasi, Ana Negri, and Marta Filizola. Bioactive conformations of two seminal delta opioid receptor penta-peptides inferred from free-energy profiles. Biopolymers, 2013. http://dx.doi.org/10.1002/bip.22251.

Ana Negri, Marie-Laure Rives, Michael J Caspers, Thomas E Prisinzano, Jonathan A Javitch, and Marta Filizola. Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. Journal of chemical information and modeling, 53(3):521{526, 2013. http://dx.doi.org/10.1021/ci400019t.

Keri L Monda, Gary K Chen, Kira C Taylor, Cameron Palmer, Todd L Edwards, Leslie A Lange, Maggie CY Ng,Adebowale A Adeyemo, Matthew A Allison, Lawrence F Bielak, et al. A meta-analysis identifies new loci associated with body mass index in individuals of african ancestry. Nature genetics, 2013. http://dx.doi.org/10.1038/ng.2608.

Clint L Miller, D Ryan Anderson, Ramendra K Kundu, Azad Raiesdana, Sylvia T Nurnberg, Roxanne Diaz, Karen Cheng, Nicholas J Leeper, Chung-Hsing Chen, I-Shou Chang, et al. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of tcf21 expression at the 6q23. 2 coronary heart disease locus. PLoS genetics, 9(7):e1003652, 2013. http://dx.doi.org/10.1371/journal.pgen.1003652.

Maria Lluch-Senar, Khai Luong, Veronica Llorens-Rico, Javier Delgado, Gang Fang, Kristi Spittle, Tyson A Clark, Eric Schadt, Stephen W Turner, Jonas Korlach, et al. Comprehensive methylome characterization of mycoplasma genitalium and mycoplasma pneumoniae at single-base resolution. PLoS genetics, 9(1):e1003191, 2013. http://dx.doi.org/10.1371/journal.pgen.1003191.

Nicholas J Leeper, Azad Raiesdana, Yoko Kojima, Ramendra K Kundu, Henry Cheng, Lars Maegdefessel, Ryuji Toh, G-One Ahn, Ziad A Ali, D Ryan Anderson, et al. Loss of cdkn2b promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, thrombosis, and vascular biology, 33(1):e1{e10, 2013. http://dx.doi.org/10.1161/ATVBAHA.112.300399.

Siamak Karkheiran, Catharine E Krebs, Vladimir Makarov, Yalda Nilipour, Benjamin Hubert, Hossein Darvish, Steven Frucht, Gholam Ali Shahidi, Joseph D Buxbaum, and Coro Paisan-Ruiz. Identification of col6a2 mutations in progressive myoclonus epilepsy syndrome. Human genetics, 132(3):275{283, 2013. http://dx.doi.org/10.1007/s00439-012-1248-1.

Yi-Juan Hu, Sonja I Berndt, Stefan Gustafsson, Andrea Ganna, Joel Hirschhorn, Kari E North, Erik Ingelsson, and Dan-Yu Lin. Meta-analysis of gene-level associations for rare variants based on single-variant statistics. The American Journal of Human Genetics, 2013. http://dx.doi.org/10.1016/j.ajhg.2013.06.011.

Ivone Gomes, Wakako Fujita, Achla Gupta, Adrian S Saldanha, Ana Negri, Christine E Pinello, Edward Roberts, Marta Filizola, Peter Hodder, and Lakshmi A Devi. Identification of a - opioid receptor heteromer-biased agonist with antinociceptive activity. Proceedings of the National Academy of Sciences, 110(29):12072{12077, 2013. http://dx.doi.org/10.1073/pnas.1222044110.

Santhi K Ganesh, Vinicius Tragante, Wei Guo, Yiran Guo, Matthew B Lanktree, Erin N Smith, Toby Johnson, Berta Almoguera Castillo, John Barnard, Jens Baumert, et al. Loci in influencing blood pressure identified using a cardiovascular gene-centric array. Human molecular genetics, 22(8):1663{1678, 2013. http://dx.doi.org/10.1093/hmg/dds555.

Sam Gandy, Vahram Haroutunian, Steven T DeKosky, Mary Sano, and Eric E Schadt. Cr1 and the "vanishing amyloid" hypothesis of alzheimer's disease. Biological psychiatry, 73(5):393, 2013. http://dx.doi.org/10.1016/j.biopsych.2013.01.013.

Zhixing Feng, Gang Fang, Jonas Korlach, Tyson Clark, Khai Luong, Xuegong Zhang, Wing Wong, and Eric Schadt. Detecting dna modifications from smrt sequencing data by modeling sequence context dependence of polymerase kinetic. PLoS computational biology, 9(3):e1002935, 2013. http://dx.doi.org/10.1371/journal.pcbi.1002935.

Nicolas Coudray, Salvatore Valvo, Minghui Hu, Ralph Lasala, Changki Kim, Martin Vink, Ming Zhou, Davide Provasi, Marta Filizola, Juoehi Tao, et al. Inward-facing conformation of the zinc transporter yiip revealed by cryoelectron microscopy. Proceedings of the National Academy of Sciences, 110(6):2140{2145, 2013. http://dx.doi.org/10.1073/pnas.1215455110.

Zhao Chen, Hua Tang, Rehan Qayyum, Ursula M Schick, Michael A Nalls, Robert Handsaker, Jin Li, Yingchang Lu, Lisa R Yanek, Brendan Keating, et al. Genome-wide association analysis of red blood cell traits in african americans: the cogent network. Human molecular genetics, 22(12):2529{2538, 2013. http://dx.doi.org/10.1093/hmg/ddt087.

Erhan Bilal, Janusz Dutkowski, Justin Guinney, In Sock Jang, Benjamin A Logsdon, Gaurav Pandey, Benjamin A Sauerwine, Yishai Shimoni, Hans Kristian Moen Vollan, Brigham H Mecham, et al. Improving breast cancer survival analysis through competition-based multidimensional modeling. PLoS computational biology, 9(5):e1003047, 2013. http://dx.doi.org/10.1371/journal.pcbi.1003047.g004.

Sonja I Berndt, Stefan Gustafsson, Reedik Magi, Andrea Ganna, Eleanor Wheeler, Mary F Feitosa, Anne E Justice, Keri L Monda, Damien C Croteau-Chonka, Felix R Day, et al. Genome-wide meta-analysis identies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature genetics, 45(5):501{512, 2013. http://dx.doi.org/10.1038/ng.2606.

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