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2018 Published Papers

1. Altman DR, Sullivan MJ, Chacko KI, Balasubramanian D, Pak TR, Sause WE, et al. Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection. Infection and immunity. 2018;86(10):e00331-18. doi: 10.1128/IAI.00331-18. PubMed PMID: 30061376.

2. Audrain M, Haure-Mirande J-V, Wang M, Kim SH, Fanutza T, Chakrabarty P, et al. Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. 2018. doi: 10.1038/s41380-018-0258-3.

3. Aushev VN, Lee E, Zhu J, Gopalakrishnan K, Li Q, Teitelbaum SL, et al. Novel Predictors of Breast Cancer Survival Derived from miRNA Activity Analysis. Clinical Cancer Research. 2018;24(3):581.

4. Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh Y-HE, et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nature Neuroscience. 2018;21(8):1049-60. doi: 10.1038/s41593-018-0192-3.

5. Barbosa M, Joshi RS, Garg P, Martin-Trujillo A, Patel N, Jadhav B, et al. Identification of rare <em>de novo</em> epigenetic variations in congenital disorders. bioRxiv. 2018.

6. Barbosa M, Joshi RS, Garg P, Martin-Trujillo A, Patel N, Jadhav B, et al. Identification of rare de novo epigenetic variations in congenital disorders. Nature communications. 2018;9(1):2064-. doi: 10.1038/s41467-018-04540-x. PubMed PMID: 29802345.

7. Bonnemaijer PWM, Iglesias AI, Nadkarni GN, Sanyiwa AJ, Hassan HG, Cook C, et al. Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. Human Genetics. 2018;137(10):847-62. doi: 10.1007/s00439-018-1943-7.

8. Cates HM, Heller EA, Lardner CK, Purushothaman I, Peña CJ, Walker DM, et al. Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing. Biological Psychiatry. 2018;84(3):167-79. doi:

9. Cates HM, Li X, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, et al. Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving. Neuropsychopharmacology. 2018;43(12):2426-34. doi: 10.1038/s41386-018-0158-x.

10. Chacko K, Sullivan M, Beckford C, Altman D, Ciferri B, Pak T, et al. The genetic basis of emerging vancomycin, linezolid, and daptomycin heteroresistance in a case of persistent Enterococcus faecium bacteremia. Antimicrobial Agents and Chemotherapy. 2018.

11. Chacko KI, Sullivan MJ, Beckford C, Altman DR, Ciferri B, Pak TR, et al. Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia. Antimicrobial agents and chemotherapy. 2018;62(4):e02007-17. doi: 10.1128/AAC.02007-17. PubMed PMID: 29339387.

12. Chen L, He Z, Iuga AC, Martins Filho SN, Faith JJ, Clemente JC, et al. Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23. Gastroenterology. 2018;155(4):1177-91.e16. doi:

13. Chen LA, Hourigan SK, Grigoryan Z, Gao Z, Clemente JC, Rideout JR, et al. Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile. Journal of Pediatric Gastroenterology and Nutrition. 2018;Publish Ahead of Print.

14. Clemente JC, Manasson J, Scher JU. The role of the gut microbiome in systemic inflammatory disease. BMJ. 2018;360.

15. Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, et al. Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimer's & Dementia. 2018;14(2):205-14. doi:

16. D’Avola D, Villacorta-Martin C, Martins-Filho SN, Craig A, Labgaa I, von Felden J, et al. High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma. Scientific Reports. 2018;8(1):11570. doi: 10.1038/s41598-018-30047-y.

17. Davenport B, Eberlein J, van der Heide V, Jhun K, Nguyen TT, Victorino F, et al. Aging of Antiviral CD8<sup>+</sup> Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing. The Journal of Immunology. 2018:ji1801277. doi: 10.4049/jimmunol.1801277.

18. Deyssenroth MA, Gennings C, Liu SH, Peng S, Hao K, Lambertini L, et al. Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. Environment International. 2018;120:373-81. doi:

19. Dong L, Wu N, Wang S, Cheng Y, Han L, Zhao J, et al. Detection of novel germline mutations in six breast cancer predisposition genes by targeted next-generation sequencing. Human Mutation. 2018;39(10):1442-55. doi: 10.1002/humu.23597.

20. Esai Selvan M, Klein RJ, Gumus ZH. Rare, pathogenic germline variants in <em>Fanconi Anemia</em> genes increase risk for squamous lung cancer. Clinical Cancer Research. 2018:clincanres.2660.018. doi: 10.1158/1078-0432.CCR-18-2660.

21. Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature genetics. 2018;50(10):141225. Epub 2018/09/17. doi: 10.1038/s41588-018-0205-x. PubMed PMID: 30224653.

22. Fazlollahi M, Chun Y, Grishin A, Wood RA, Burks AW, Dawson P, et al. Early-life gut microbiome and egg allergy. Allergy. 2018;73(7):1515-24. doi: 10.1111/all.13389.

23. Fazlollahi M, Chun Y, Grishin A, Wood RA, Burks AW, Dawson P, et al. Early‐life gut microbiome and egg allergy. Allergy. 2018;0(0). doi: 10.1111/all.13389.

24. Fazlollahi M, Lee TD, Andrade J, Oguntuyo K, Chun Y, Grishina G, et al. The nasal microbiome in asthma. Journal of Allergy and Clinical Immunology. 2018;142(3):834-43.e2. doi:

25. Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, et al. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC obesity. 2018;5:26-. doi: 10.1186/s40608-018-0200-x. PubMed PMID: 30305909.

26. Filizola M. Insights from molecular dynamics simulations to exploit new trends for the development of improved opioid drugs. Neuroscience Letters. 2018. doi:

27. Fu J, Wang Z, Lee K, Wei C, Liu Z, Zhang M, et al. Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis. Kidney International. 2018;93(2):416-29. doi:

28. Fu J, Wei C, Zhang W, Schlondorff D, Wu J, Cai M, et al. Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic mice. Kidney International. 2018;94(2):326-45. doi: 10.1016/j.kint.2018.02.028.

29. Galatioto J, Caescu CI, Hansen J, Cook JR, Miramontes I, Iyengar R, et al. <span hwp:id="article-title-1" class="article-title">Cell Type–Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease—Brief Report</span><span hwp:id="article-title-15" class="sub-article-title">Highlights</span&gt. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38(3):588.

30. Galsky MD, Wang H, Hahn NM, Twardowski P, Pal SK, Albany C, et al. Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes. European Urology. 2018;73(5):751-9. doi:

31. Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018;362(6420):eaat8127. doi: 10.1126/science.aat8127.

32. Gaspari S, Purushothaman I, Cogliani V, Sakloth F, Neve RL, Howland D, et al. Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway. Proceedings of the National Academy of Sciences. 2018;115(9):E2085. doi: 10.1073/pnas.1707887115.

33. Gaspari S, Purushothaman I, Cogliani V, Sakloth F, Neve RL, Howland D, et al. Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/beta-catenin pathway. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(9):E2085-e94. Epub 2018/02/15. doi: 10.1073/pnas.1707887115. PubMed PMID: 29440403.

34. Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, et al. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. Nature Communications. 2018;9(1):391. doi: 10.1038/s41467-017-02762-z.

35. Girdhar K, Hoffman GE, Jiang Y, Brown L, Kundakovic M, Hauberg ME, et al. Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome. Nature Neuroscience.
2018;21(8):1126-36. doi: 10.1038/s41593-018-0187-0.

36. Gómez S, Garrido-Garcia A, Garcia-Gerique L, Lemos I, Suñol M, de Torres C, et al. A novel method for rapid molecular subgrouping of medulloblastoma. Clinical Cancer Research. 2018.

37. Gómez S, Garrido-Garcia A, Garcia-Gerique L, Lemos I, Suñol M, de Torres C, et al. A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma. Clinical Cancer Research. 2018;24(6):1355. doi: 10.1158/1078-0432.CCR-17-2243.

38. Gong J, Nishimura KK, Fernandez-Rhodes L, Haessler J, Bien S, Graff M, et al. Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. International journal of obesity (2005).
2018;42(3):384-90. Epub 2017/12/21. doi: 10.1038/ijo.2017.304. PubMed PMID: 29381148.

39. Haure-Mirande J-V, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, et al. Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. 2018. doi: 10.1038/s41380-018-0255-6.

40. Hefti MM, Farrell K, Kim S, Bowles KR, Fowkes ME, Raj T, et al. High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. PLOS ONE. 2018;13(4):e0195771. doi: 10.1371/journal.pone.0195771.

41. Hodonsky CJ, Schurmann C, Schick UM, Kocarnik J, Tao R, van Rooij FJA, et al. Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE study. American Journal of Hematology. 2018;93(8):1061-73. doi: 10.1002/ajh.25161.

42. Holmes G, Rourke C, Motch Perrine SM, Lu N, van Bakel H, Richtsmeier JT, et al. Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development. 2018;145(19):dev166488. doi: 10.1242/dev.166488.

43. Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, et al. Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations. The Journal of Clinical Endocrinology & Metabolism. 2018:jc.2017-01802-jc.2017-. doi: 10.1210/jc.2017-01802.

44. Hong J, Hatchell KE, Bradfield JP, Bjonnes A, Chesi A, Lai C-Q, et al. Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. The Journal of Clinical Endocrinology & Metabolism. 2018;103(4):1380-92. doi: 10.1210/jc.2017-01802.

45. Hu Y, Raffield LM, Polfus LM, Moscati A, Nadkarni G, Preuss MH, et al. A common <em>TCN1</em> loss-of-function variant is associated with lower vitamin B<sub>12</sub> concentration in African Americans. Blood. 2018;131(25):2859. doi: 10.1182/blood-2018-03-841023.

46. Huang F, Wang M, Liu R, Wang J-Z, Schadt E, Haroutunian V, et al. CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease. Alzheimer's & Dementia. 2018. doi:

47. Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, et al. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nature Structural & Molecular Biology. 2018;25(1):53-60. doi: 10.1038/s41594-017-0009-1.

48. Kajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, et al. GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis. Acta neuropathologica communications. 2018;6(1):144-. doi: 10.1186/s40478-018-0642-x. PubMed PMID: 30577786.

49. Kalayci S, Esai Selvan M, Ramos I, Cotsapas C, Montgomery RR, Poland G, et al. ImmuneRegulation: A web-based tool for identifying human immune regulatory elements. bioRxiv. 2018:468124. doi: 10.1101/468124.

50. Kalayci S, Gümüş ZH. Exploring Biological Networks in 3D, Stereoscopic 3D, and Immersive 3D with iCAVE. Current Protocols in Bioinformatics. 2018;61(1):8.27.1-8..6. doi: 10.1002/cpbi.47.

51. Kasarskis A, Di Narzo AF, Kidd B, Argmann C, Dudley J, Cho J, et al. High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease. 2018. doi: 10.1093/ecco-jcc/jjy190.

52. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, et al. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Systems. 2018;6(1):13-24. doi:

53. Kozlenkov A, Li J, Apontes P, Hurd YL, Byne WM, Koonin EV, et al. A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons. Science advances. 2018;4(9):eaau6190-eaau. doi: 10.1126/sciadv.aau6190. PubMed PMID: 30263963.

54. Labgaa I, Villacorta-Martin C, D'Avola D, Craig AJ, von Felden J, Martins-Filho SN, et al. A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. Oncogene. 2018;37(27):3740-52. Epub 2018/04/09. doi: 10.1038/s41388-018-0206-3. PubMed PMID: 29628508.

55. Laverty KU, Stout JM, Sullivan MJ, Shah H, Gill N, Holbrook L, et al. A physical and genetic map of Cannabis sativa identifies extensive rearrangement at the THC/CBD acid synthase locus. Genome Research. 2018.

56. Li H, Zhang W, Zhong F, Das GC, Xie Y, Li Z, et al. Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury. Kidney International. 2018;94(6):1160-76. doi: 10.1016/j.kint.2018.07.023.

57. Li W, Middha M, Bicak M, Sjoberg DD, Vertosick E, Dahlin A, et al. Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival. European Urology. 2018;74(6):710-9. doi: 10.1016/j.eururo.2018.06.021.

58. Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American journal of human genetics. 2018;103(5):691-706. Epub 2018/11/01. doi: 10.1016/j.ajhg.2018.09.009. PubMed PMID: 30388399.

59. Linde N, Casanova-Acebes M, Sosa MS, Mortha A, Rahman A, Farias E, et al. Macrophages orchestrate breast cancer early dissemination and metastasis. Nature Communications. 2018;9(1):21. doi: 10.1038/s41467-017-02481-5.

60. Llewellyn SR, Britton GJ, Contijoch EJ, Vennaro OH, Mortha A, Colombel J-F, et al. Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice. Gastroenterology. 2018;154(4):1037-46.e2. doi:

61. Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Wright WJ, Salery M, et al. Zfp189 Mediates Stress Resilience Through a CREB-Regulated Transcriptional Network in Prefrontal Cortex. bioRxiv. 2018:403733. doi: 10.1101/403733.

62. Lorsch ZS, Loh Y-HE, Purushothaman I, Walker DM, Parise EM, Salery M, et al. Estrogen receptor α drives pro-resilient transcription in mouse models of depression. Nature Communications. 2018;9(1):1116. doi: 10.1038/s41467-018-03567-4.

63. Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature genetics. 2018;50(11):1505-13. Epub 2018/10/08. doi: 10.1038/s41588-018-0241-6. PubMed PMID: 30297969.

64. Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature genetics. 2018;50(4):559-71. Epub 2018/04/09. doi: 10.1038/s41588-018-0084-1. PubMed PMID: 29632382.

65. Manasson J, Shen N, Garcia Ferrer Helga R, Ubeda C, Iraheta I, Heguy A, et al. Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. Arthritis & Rheumatology. 2018;70(2):242-54. doi: 10.1002/art.40359.

66. Manheimer Kathryn B, Patel N, Richter F, Gorham J, Tai Angela C, Homsy J, et al. Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors. Human Mutation. 2018;39(6):870-81. doi: 10.1002/humu.23419.

67. Manheimer KB, Patel N, Richter F, Gorham J, Tai AC, Homsy J, et al. Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors. Human Mutation. 2018;39(6):870-81. doi: 10.1002/humu.23419.

68. Manheimer KB, Richter F, Edelmann LJ, D’Souza SL, Shi L, Shen Y, et al. Robust identification of mosaic variants in congenital heart disease. Human Genetics. 2018;137(2):183-93. doi: 10.1007/s00439-018-1871-6.

69. Marino KA, Filizola M. Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics Simulations. Methods in molecular biology (Clifton, NJ). 2018;1705:351-64. doi: 10.1007/978-1-4939-7465-8_17. PubMed PMID: PMC5745006.

70. Martinelli S, Krumbach OHF, Pantaleoni F, Coppola S, Amin E, Pannone L, et al. Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes. American journal of human genetics. 2018;102(2):309-20. Epub 2018/01/25. doi: 10.1016/j.ajhg.2017.12.015. PubMed PMID: 29394990.

71. Mayourian J, Ceholski DK, Gonzalez DM, Cashman TJ, Sahoo S, Hajjar RJ, et al. Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling. Circulation research. 2018;122(1):167-83. doi: 10.1161/CIRCRESAHA.117.311589. PubMed PMID: 29301848.

72. McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3):e00031-18. doi: 10.1128/mSystems.00031-18.

73. McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A, et al. Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. Scientific Reports. 2018;8(1):8868. doi: 10.1038/s41598-018-27293-5.

74. Mena J, Brito B, Moreira R, Tadich T, González I, Cruces J, et al. Reemergence of H3N8 Equine Influenza A virus in Chile, 2018. Transboundary and Emerging Diseases. 2018;65(6):1408-15. doi: 10.1111/tbed.12984.

75. Meral D, Provasi D, Filizola M. An efficient strategy to estimate thermodynamics and kinetics of G protein-coupled receptor activation using metadynamics and maximum caliber. The Journal of Chemical Physics. 2018;149(22):224101. doi: 10.1063/1.5060960.

76. Meral D, Provasi D, Prada-Gracia D, Möller J, Marino K, Lohse MJ, et al. Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations. Scientific Reports. 2018;8(1):7705. doi: 10.1038/s41598-018-26070-8.

77. Mezei M. Revisiting Chameleon Sequences in the Protein Data Bank. Algorithms. 2018;11(8). doi: 10.3390/a11080114.

78. Miller ML, Chadwick B, Dickstein DL, Purushothaman I, Egervari G, Rahman T, et al. Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons. Molecular Psychiatry. 2018. doi: 10.1038/s41380-018-0243-x.

79. Miller ML, Ren Y, Szutorisz H, Warren NA, Tessereau C, Egervari G, et al. Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. Molecular psychiatry. 2018;23(5):1328-35. Epub 2017/04/25. doi: 10.1038/mp.2017.80. PubMed PMID: 28439100.

80. Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, et al. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. The American Journal of Human Genetics. 2018;102(1):103-15. doi:

81. Pandey G, Pandey OP, Rogers AJ, Ahsen ME, Hoffman GE, Raby BA, et al. A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data. Scientific Reports. 2018;8(1):8826. doi: 10.1038/s41598-018-27189-4.

82. Polfus LM, Raffield LM, Wheeler MM, Tracy RP, Lange LA, Lettre G, et al. Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans. Human Molecular Genetics. 2018:ddy360-ddy. doi: 10.1093/hmg/ddy360.

83. Qian T, Zhu S, Hao K, Hoshida Y, Shen Y, Yu J. GIGSEA: genotype imputed gene set enrichment analysis using GWAS summary level data. Bioinformatics. 2018;35(1):160-3. doi: 10.1093/bioinformatics/bty529.

84. Rahman AH, Lavin Y, Kobayashi S, Leader A, Merad M. High-dimensional single cell mapping of cerium distribution in the lung immune microenvironment of an active smoker. Cytometry Part B: Clinical Cytometry. 2018;94(6):941-5. doi: 10.1002/cyto.b.21545.

85. Raj T, Li YI, Wong G, Humphrey J, Wang M, Ramdhani S, et al. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility. Nature Genetics. 2018;50(11):1584-92. doi: 10.1038/s41588-018-0238-1.

86. Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, et al. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science. 2018;362(6420):eaat4311. doi: 10.1126/science.aat4311.

87. Ramdhani S, Navarro E, Udine E, Schilder BM, Parks M, Raj T. Tensor Decomposition of Stimulated Monocyte and Macrophage Gene Expression Profiles Identifies Neurodegenerative Disease-specific <em>Trans</em>-eQTLs. bioRxiv. 2018:499509. doi: 10.1101/499509.

88. Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, et al. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. PLoS genetics. 2018;14(11):e1007427-e. doi: 10.1371/journal.pgen.1007427. PubMed PMID: 30388101.

89. Readhead B, Hartley BJ, Eastwood BJ, Collier DA, Evans D, Farias R, et al. Expression-based drug screening of neural progenitor cells from individuals with schizophrenia. Nature Communications. 2018;9(1):4412. doi: 10.1038/s41467-018-06515-4.

90. Reiner J, Pisani L, Qiao W, Singh R, Yang Y, Shi L, et al. Cytogenomic identification and long-read single molecule real-time (SMRT) sequencing of a Bardet-Biedl Syndrome 9 (BBS9) deletion. NPJ genomic medicine. 2018;3:3-. doi: 10.1038/s41525-017-0042-3. PubMed PMID: 29367880.

91. Rejwan Ali M, Sadoqi M, Boutajangout A, Mezei M. Virtual screening of a natural compound library at orthosteric and allosteric binding sites of the neurotensin receptor. Journal of Biomolecular Structure and Dynamics. 2018:1-13. doi: 10.1080/07391102.2018.1552200.

92. Ren C, Zhang G, Han F, Fu S, Cao Y, Zhang F, et al. Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proceedings of the National Academy of Sciences. 2018;115(31):7949. doi: 10.1073/pnas.1720000115.

93. Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, et al. Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine. Nature communications. 2018;9(1):3149-. doi: 10.1038/s41467-018-05657-9. PubMed PMID: 30089879.

94. Rimondi A, Gonzalez-Reiche AS, Olivera VS, Decarre J, Castresana GJ, Romano M, et al. Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006-2016). Emerging microbes & infections. 2018;7(1):194-. doi: 10.1038/s41426-018-0190-2. PubMed PMID: 30482896.

95. Roselli C, Chaffin MD, Weng L-C, Aeschbacher S, Ahlberg G, Albert CM, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nature genetics. 2018;50(9):1225-33. Epub 2018/06/11. doi: 10.1038/s41588-018-0133-9. PubMed PMID: 29892015.

96. Saccone NL, Emery LS, Sofer T, Gogarten SM, Becker DM, Bottinger EP, et al. Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Nicotine & Tobacco Research. 2018;20(4):448-57. doi: 10.1093/ntr/ntx107.

97. Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, et al. Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome Medicine. 2018;10(1):26. doi: 10.1186/s13073-018-0530-9.

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