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Pyramidal neuron from the prefrontal cortex of a rhesus monkey brain. Reconstruction prepared by theVisualMD.

The Morrison Laboratory works on synaptic plasticity, the aging brain, and the synaptic basis of age-related cognitive decline. They are particularly interested in the distinction between Alzheimer’s disease and the more modest disruption of memory often referred to as age-associated cognitive impairment that often occurs in the context of normal aging. Minerva was utilized to compare the neurons of young and aged monkeys that have had extensive assessment of their cognitive capabilities.

By extracting the structural details of the neurons and revealing which neuronal changes correlate with age, we may help in the creation of new treatments that protect the neurons and retain youthful cognitive function.

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